Gel carbomer 940 pdf

In addition, carbopol is used in the cosmetic industry. Acute oral animal studies showed that carbomers910, 934, 934p, 940. For the thickener, i have carbomer 940, which is a polyvinyl carboxy polymer. Because of the way carbomer works, it is very rare for anybody to have any reaction to carbomer.

Carbomer base carbomer is a polymer that will swell when in contact with water. Carbomer homopolymer type c former carbomer 940 by u. Common gelling agents university of north carolina at. Each gram of gel contains 2mg carbomer polyacrylic acid as the active ingredient. I used polysorbate 80 because i read in an article that it could help hold the ipa in a carbomer gel, same reason i used pg. The key to easy formulation of gels and suspension products. It is easier to add the active drug before the gel is formed if the drug doesnt interfere with the gel formation. Gel was stable, clarity was better than that with carbopol 940. I also bought some tea polyvinyl carboxy polymer which makes the carbomer solution more alkaline and causes it to thicken more. Transdermal gel formulation containing glibenclamide can be prepared by direct dispersion method, using carbopol 940 as a. One of the most widely used carbomers however is carbomer 940.

The preferred polymer is a carbomer resin that forms a slightly gelatinous mass through hydration of the polymer. I used 940 because it is the cheapest, the other varieties are at least double the price. Rheological characterization of topical carbomer gels. United states pharmacopeianational formulary uspnf monograph for carbomer 940 general product characteristics appearance. Utilized in pharmaceutical products as rheology modifiers, tablet binders, suspension stabilizers, extended release polymers, mucoadhesive aids, and bioavailability enhancers, carbopol polymers are well known for their. First carbomer on the market based on class 3 solvent nheptane ethylacetate, according to pharmacopoes. Carbomer is a homopolymer of acrylic acid crosslinked with an allyl ether of pentaerythritol, an allyl ether of sucrose, or an allyl ether of propylene. This study was designed to investigate the applicability of carbomer 940 hydrogel on skin. The primary objective of this study is to perform detailed and extensive rheological characterization of rheology. Neutralization can be carried out with inorganic bases such as naoh or koh or triethanolamine tea.

Im finding that the carbomer tends to make your hands feel sticky just before the sanitizer is completely dried. What carbomer looks like and contents of the pack carbomer is a clear sterile liquid gel. Carbomer 940 should then be allowed to swellhydrate. Pdf viscoelastic properties of carbopol 940 gels and. Backgroundaims carbomers are widely used in products for the treatment of dry eye. Carbomer 940 the key to easy formulation of gels and suspension products. The study concerns with the theological behaviour of carbopol940 hydrogel at different concentrations. Uses advised against food, drug, pesticide or biocidal product use. As threedimensionally crosslinked microgels, carbomers do not dissolve but swell to a remarkable extent in water after neutralization to form a gel. Us5508029a isopropyl alcohol gel composition and process. It is a viscosity modifier, stabilizer, dispersant and emulsifier. Slightly acetic test specification lot test frequency1. Carbomer codes 910, 934, 940, 941, and 934p are an indication of molecular weight and the specific components of the polymer. Carbopol 940 nf polymer meets the limits cited in the current edition of the.

Carbomer not only thickens a product, but will bring stability and texture enhancement. Sanitizer become very cloudy not transparent my question is i am mixing correct product or is there any substitutes for carbomer 940 thanks. Carbopol ultrez 10 polymer can replace carbopol 940 polymer and carbopol 980 polymer for applications requiring easy processing and a carbomer inci name, such. Rheological characterization of topical carbomer gels neutralized to different ph mohammad t. Carbopol 940 is a polyvinyl carboxy polymer used as a viscosity enhancer or gelling agent. Carbomer is the main part of almost every cosmetics and pharmaceutical product which is offered as a gel, from cosmetic glitter gels to cuticle removers to gel toothpastes. Formulation and in vitro evaluation of carbopol 934based. Carbomers are white, fluffy powders but are frequently used as gels in cosmetics and personal care products. Carbomer pregel how to make a gel using carbomer 940 carbomer 940 is classed as a gelling agent and forms clear gels.

Formulation gel used carbopol 940 as gelling aget and sorbitol as humectant. Gelcreams, hair gels, and other gels, lotions, creams. Since their creation as the first commercial carbomers over 50 years ago, lubrizols carbopol polymers have continued to be the highest quality carbomers on the market. Formulation and development ph induced insitu gelling system of. Rheological characterization of topical carbomer gels neutralized to different ph article pdf available in pharmaceutical research 217. Clear eye gel sample recipe for carbomer clear eye gel skin tightening and moisturizing phase a weight % for 50 g 1. For many applications paas are used in form of alkali metal or ammonium salts, e.

Things to consider before you start to use carbomer 980 0. This research aimed to determine the optimum composition of carbopol 940 and sorbitol and their interactions in determining the stability of gel, as well as to get the optimum area of antiacne gel formulation leaf extract binahong. As with any polyacrylatebased water thickener like carbopol 940, the key is to ensure you are at the correct ph. Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k. Carbomer for cosmetic use to thicken and viscosity adjust gel. By changing the usage level, you can create a stable free flowing product to a very stiff hair gel.

I have seen 940 used in various commercial aloe gels so i thought it might work with aloe. The polymer is dispersed in water to create a thick phase. It is one of a group of eye drops called artificial tears. Request pdf effects of carbomer 940 hydrogel on burn wounds.

Behaviour of carbopol ultrez 10 hydrogels was studied in regard to the polymer concentration and ph of the gel. A novel method of radiolabelling carbomer gels, with minimum change to their rheology, has permitted. The socalled ultrasonic conducting gel or contact gel for ultrasound is an aqueous or hydroalcoholic gel of carbopol 940 to which more or less alcohol is added as desired more or less refreshing. It is a proven exceptional thickener, suspending agent and stabilizer utilized in a wide variety of personal care products. The carbomer gel also significantly improved the rose bengal staining score relative to placebo. It can be used to thicken the water for a lotion or making a gel base for a skin serum or hair styling. Carbomer also contains the inactive ingredients cetrimide as a preservative, sorbitol, sodium hydroxide and water for injection.

Carbomer 940 is a polyvinyl carboxy polymer used as a viscosity enhancer, gelling agent, or. Ocular contact time of a carbomer gel geltears in humans. Find patient medical information for carbomer gelaqueous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Final report on the safety assessment of carbomers934. By studying the various rheological properties of carbopol gels under a. Formulation and evaluation of topical herbal gel for the. Viscoelastic properties of carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases article pdf available in pharmaceutical research 2212. With that much ethanol, ph measurement can be difficult, so maybe take out the ethanol and see what the ph is or thickening power is without the etoh. Carbomers can be found in a wide variety of product types including skin. Hand sanitizer gel having important ingredients that are ethyl alcohol or isopropyl alcohol or together used in the same mixture,carbomer used for thickness, glycerine to protect hand outside,preservative agent to protect products etc. The isopropyl alcohol gel of the present invention comprises a polymer, water, isopropyl alcohol and a polymer neutralizing agent. Thickner agents in hand sanitizer cosmetic science talk.

I have make hand sanitizer and in this i have use carbomer 940 as a thickner agents but i am facing problem with 940. Hello every one, i did experiment on carbomer preparation, as iam a student, i did this experiment in my student lab, we did mistake by using hot water so hope you understand my practical, thumbs. Carbomer is a term used for a series of polymers primarily made from acrylic acid. An isopropyl alcohol gel having use as a rubbing composition and having antiseptic properties. Safety data sheet revision date 29apr2020 revision number 4 1. Carbomer carbopol 940 for hand sanitizer gel china. When data for the primary subjective efficacy variables were stratified for disease severity, there was a statistically significant improvement from baseline by day 10 for severely affected patients and from day 42 for patients with moderate disease.

The carbomer polymers are used in cosmetics and emulsifying agents at concentrations up to 50%. Carbomer is an extremely efficient rheology modifier capable of providing high viscosity and forms. As with gums, carbomer 940 should be put into a dry container to which the amount of room temperature distilleddeionized water, in your formula, will be added. Pdf rheological characterization of topical carbomer. Solvent type, polymer concentration, gel preparation, mechanical properties.